Urology · Educational animation
90 seconds

Histotripsy for a kidney mass

Histotripsy is being studied for kidney masses. Here is how it works.

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Review this 90-second patient- and referrer-facing animation about renal histotripsy.

Watch page: https://nyu-histotripsy-kidney.pages.dev/
Landscape MP4: https://nyu-histotripsy-kidney.pages.dev/nyu-histotripsy-kidney.mp4
Captioned vertical MP4: https://nyu-histotripsy-kidney.pages.dev/nyu-histotripsy-kidney-vertical.mp4
Narration transcript: https://nyu-histotripsy-kidney.pages.dev/transcript.txt
Clinical sources and limits: https://nyu-histotripsy-kidney.pages.dev/sources.txt
Timestamped video stills: https://nyu-histotripsy-kidney.pages.dev/review-stills.jpg

First state whether you could watch the full video and hear its audio. If you cannot access either, say so and ask me to upload the MP4. Do not imply that you watched motion or heard narration if you only read the transcript or viewed stills.

Assess: anatomical accuracy; water coupling and ultrasound targeting; a bubble cloud confined to the focus; treatment of the mass plus a planned margin; mechanical, nonthermal tissue breakdown; the distinction between a fluid-filled treated area and the explicit fluid-hidden illustration; and the Later time jump before possible resorption. Check for unsupported claims about efficacy, safety, renal authorization, availability or recovery. Verify proposed medical corrections against primary sources.

Also assess patient-level clarity, narration and pronunciation, pace, visual continuity, text and caption readability on a phone, and the end card. Separate factual errors from preferences.

Return: (1) a brief overall assessment; (2) a timestamped table with severity P0/P1/P2, observed problem, why it matters, and a concrete fix; (3) the five most useful changes in priority order; and (4) any revised narration, with a source for each added factual claim. P0 means a factual or serious visual error that must be fixed before sharing; P1 materially improves clarity; P2 is polish. Note which findings you could not verify. Do not invent statistics or guarantee results.

Timestamped video stills · Narration transcript · Clinical sources and limits

Narration transcript

Histotripsy for a kidney mass
90-second narration transcript

0:00–0:08
Histotripsy is being studied for kidney masses. Here is how it works.

0:08–0:18
The patient lies on their side. A water bath against the skin links the treatment head to the body.

0:18–0:29
Ultrasound imaging helps the team locate the mass and plan the treatment area, including a margin around it.

0:29–0:46
Short sound pulses pass through the skin without an incision. They meet at a small focus, where tiny bubbles form, expand, and collapse. This breaks tissue apart mechanically. Heat is not the treatment mechanism.

0:46–0:59
The focus moves through the planned area. Solid tissue breaks down into fluid containing tiny cell fragments, called acellular debris.

0:59–1:12
We hide the fluid in this illustration to show the space inside the treated area. The kidney's outer contour remains visible.

1:12–1:23
Later, the body can clear the broken-down material, and the treated area can shrink. This change takes time.

1:23–1:30
The team uses imaging and clinical assessment to decide whether a kidney mass can be treated.

Clinical sources

The cavity view explicitly hides the fluid as a teaching illustration. “Later” marks a time jump; the film gives no healing timetable or outcome rate.

Wah et al. CAIN feasibility trial protocol, 2025
Abstract; Histotripsy Device; Index-Procedure Ultrasound Imaging Inclusion/Exclusion; Histotripsy Treatment. Primary renal protocol, not outcome evidence.
Wah et al. Early Clinical Histotripsy Treatment of Renal Cell Carcinoma, 2025
Treatment-position and planning paragraphs; later imaging paragraph; procedural considerations. One renal case, not a rate or general prognosis.
NYU Langone: Histotripsy Makes Its Clinical Debut in NYC
Opening mechanism paragraph. Describes cavitation, acellular debris and reabsorption. Clinical service described is liver; do not transfer its outcomes or recovery claims to kidney.
Hall et al. Histotripsy of rabbit renal tissue in vivo: temporal histologic trends, 2007
Abstract results/conclusions. Animal renal tissue; later resorption, fibrosis and a contour defect were reported. No human timing or unchanged-contour guarantee.
NYU renal histotripsy research listing
Brief description; trial identifier NCT05820087. Supports renal research context only.
NCI renal histotripsy trial listing
Description; status closed to accrual. Guard against an unsupported recruitment invitation. Trial and device names stay in sources, outside the film.